Impaired lymphocyte transformation and capping in autoimmune thrombocytopenic purpura

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Impaired lymphocyte transformation and capping in autoimmune thrombocytopenic purpura.

Alterations in lymphocyte function and the role of cell-mediated immunity have been studied in patients with autoimmune thrombocytopenic purpura (ATP). The numbers of T cells, B cells, and null cells were 62 ± 4.0 %, 5.4 ± 0.8 %. and 33 %, respectively, in 43 patients and were no different than those found in 33 control measurements in normal subjects. In 31 ATP patients an inverse relationship...

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Abnormal autologous mixed lymphocyte reaction in autoimmune thrombocytopenic purpura.

The autologous mixed lymphocyte reaction (auto-MLR) measures the ability of non-T cells to stimulate autologous T cells to proliferate in tissue culture. The auto-MLR was studied in 11 patients with autoimmune thrombocytopenic purpura (ATP). Seven patients had decreased auto-MLR, which averaged 4440 +/- 3364 cpm (SEM) compared to 15,360 +/- 6905 cpm for simultaneously studied controls. The aver...

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Autoimmune thrombocytopenic purpura.

Adult autoimmune throbocytopenic purpura (ATP) is a platelet disorder that develops in certain individuals with a genetic as well as sex (female) predisposition following an environment event (?viral). This results in the production of an IgG antiplatelet antibody capable of reacting with the host's platelets, as well as crossing the placenta. This leads to the rapid clearance and destruction o...

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Correlations among age, cytokines, lymphocyte subtypes, and platelet counts in autoimmune thrombocytopenic purpura.

While autoimmune thrombocytopenic purpura is mediated by autoantibodies, accumulating evidence suggests that T helper cells and the cytokines they produce also play a key role. We determined correlations among age, serum cytokine concentrations, circulating lymphocyte, and platelet counts in adult (n=19) and children (n=29) with autoimmune thrombocytopenic purpura. Correlations between age and ...

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Immune pathophysiology of autoimmune thrombocytopenic purpura.

Chronic autoimmune thrombocytopenic purpura (AITP) is an immune-mediated, bleeding disorder in which platelets are opsonized by autoantibodies and prematurely destroyed by phagocytic cells in the reticuloendothelial system. It is classed as an organ-specific autoimmune disease primarily mediated by immunoglobulin G (IgG) autoantibodies and its etiology appears to be similar to that observed for...

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ژورنال

عنوان ژورنال: Blood

سال: 1979

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v53.3.341.bloodjournal533341